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Drug Interactions With Zalcitabine

As with any medication, there are potential drug interactions with zalcitabine. Combining it with other medications, such as certain antibiotics, can change the levels of zalcitabine in your blood. As a result, these interactions can increase your risk of side effects or decrease the effectiveness of zalcitabine. Check with your healthcare provider before taking zalcitabine with any other medications.

Drug Interactions With Zalcitabine: An Introduction

(This medication is no longer available. This medication was not discontinued for safety reasons. The manufacturer of zalcitabine chose to stop making it because current HIV treatment guidelines recommended using newer medications, rather than zalcitabine.)


Zalcitabine (Hivid®) can potentially interact with a few other medicines. Some of these medicines that may lead to zalcitabine interactions include:
  • Antacids that contain magnesium or aluminum
  • Certain antibiotics or antifungal medications, including:


    • Amikacin (Amikin®)
    • Amphotericin B (Abelcet®, AmBisome®, Amphotec®, Fungizone®)
    • Chloramphenicol (Chloromycetin®)
    • Dapsone (Aczone®)
    • Ethionamide (Trecator-SC®)
    • Gentamicin
    • Isoniazid
    • Kanamycin (Kantrex®)
    • Metronidazole (Flagyl®)
    • Neomycin (Neo-Fradin®)
    • Nitrofurantoin (Macrobid, Macrodantin®)
    • Streptomycin
    • Tobramycin


Zalcitabine Drug Information

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