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Drug Interactions With Ulipristal

When medications such as barbiturates, bosentan, or St. John's wort are taken with ulipristal, drug interactions may occur. These reactions could decrease the amount of ulipristal in your blood, possibly increasing your risk of pregnancy. To help reduce your risk for complications, make sure to tell your healthcare provider if you are taking any other medications before using ulipristal.

An Overview of Ulipristal Interactions

Ulipristal acetate (ella®) can potentially interact with several other medications. Some of the medicines that may lead to drug interactions with this product include but are not limited to:
  • Barbiturates, such as:
    • Amobarbital (Amytal®)
    • Butalbital (Fioricet®, Fiorinal®)
    • Pentobarbital (Nembutal®)
    • Phenobarbital (Luminal®)
    • Secobarbital (Seconal®)

More Detail on Drug Interactions With Ulipristal

All of the medications listed above could theoretically decrease the level of ulipristal in your blood, possibly increasing the chance of becoming pregnant.
Women are not typically advised to stop taking any medication just because of a possible drug interaction with ulipristal. Most of the medications that may, theoretically, interact with ulipristal do so because they cause the liver to break down (metabolize) ulipristal too quickly. Stopping these medications temporarily is not likely to help much, as the liver will not adjust right away.
However, if you have any concerns about possible drug interactions, you should not hesitate to contact your healthcare provider.
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Ulipristal Drug Information

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