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More Medicines That Interfere With Tri-Sprintec

Many Seizure Medications
Some seizure medications may cause your body to metabolize the hormones in Tri-Sprintec too quickly, possibly increasing your risk of pregnancy. Ask your healthcare provider if you should use a different method of contraception while taking a seizure medication.
 
Modafinil (Provigil)
Modafinil may make Tri-Sprintec less effective, possibly increasing your risk of pregnancy. Talk with your healthcare provider, as you may need to use a backup method of contraception.
 
Protease Inhibitors
Combining Tri-Sprintec with a protease inhibitor may increase your risk of pregnancy and may make the protease inhibitor less effective. Talk with your healthcare provider before using these medications together.
 
Selegiline (Eldepryl, Emsam, Zelapar)
The hormones in Tri-Sprintec may increase the level of selegiline in your blood, possibly increasing your risk of side effects. Your healthcare provider may need to lower your selegiline dosage or recommend an alternate form of contraception.
 
St. John's Wort
St. John's wort (a commonly used herbal supplement) may decrease the effectiveness of Tri-Sprintec, possibly increasing the chance of pregnancy. In general, you should not take St. John's wort while using Tri-Sprintec.
 
Theophylline (Uniphyl, Theocron, TheoCap, Theo-24, Elixophyllin)
Tri-Sprintec may increase the level of theophylline in your blood, which could increase the chance of theophylline side effects. Talk with your healthcare provider before taking these medications together. Your theophylline dose may need to be reduced, or you may need to switch to a different method of contraception.
 

Final Thoughts on Drug Interactions With Tri-Sprintec

It is possible that not all drug interactions with Tri-Sprintec were discussed in this article. Therefore, you should talk with your pharmacist or healthcare provider about the specific drug interactions that may apply to you.
 
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