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Precautions and Warnings With Tipranavir

Talk to your healthcare provider about the precautions and warnings with tipranavir to help ensure that the drug is suitable for you. Tipranavir may cause problems in people with liver disease, hemophilia, or diabetes. Precautions and warnings with tipranavir also apply to people who are allergic to any components of the medication, have liver disease, or are taking drugs that may interact with tipranavir.

Tipranavir: What Should I Tell My Healthcare Provider?

You should talk with your healthcare provider prior to taking tipranavir (Aptivus®) if you have:
Also, let your healthcare provider know if you are:
  • Pregnant or thinking of becoming pregnant
  • Breastfeeding.
You should also be sure to tell your healthcare provider about all other medicines you are taking, including prescription and non-prescription medicines, vitamins, and herbal supplements.

Specific Precautions and Warnings With Tipranavir

Warnings and precautions to be aware of prior to taking tipranavir include the following:
  • There have been reports of bleeding in the brain in people taking tipranavir. Some of these cases were fatal.
  • Tipranavir can increase the risk of bleeding. Let your healthcare provider know if you have any unusual or unexplained bruising or bleeding while taking it.
  • Tipranavir must be taken with ritonavir (Norvir®), another HIV medication. Taking tipranavir without ritonavir will decrease the level of tipranavir in your blood, making it less effective.
  • The liver helps to remove the medication from the blood. Therefore, if you have liver disease, tipranavir may make it worse. Make sure to tell your healthcare provider if you already have liver disease or liver damage prior to starting treatment.
  • Tipranavir can cause high blood sugar (hyperglycemia). This can cause problems for people with diabetes, or it can even cause diabetes in individuals who are at risk for the condition.
  • Tipranavir is a sulfonamide ("sulfa") drug. If you have a sulfa allergy, do not take tipranavir without discussing it with your healthcare provider first.
  • The medication can increase triglyceride and cholesterol levels. Your healthcare provider should monitor your cholesterol and triglyceride levels while you are taking tipranavir.
  • There have been reports of bleeding possibly due to protease inhibitors (such as tipranavir) in people with hemophilia. Be sure your healthcare provider knows if you have this condition.
  • Tipranavir can change the distribution of fat on your body. You may gain fat in areas that are not typical for you, such as in the abdomen or at the back of the neck (a "buffalo hump"), and may lose weight in other areas.
  • Tipranavir is not a cure for HIV or AIDS. If you have HIV or AIDS, you should always use safer sex practices, whether or not you are taking medications.
  • As with all HIV medications, it is important that you take tipranavir exactly as prescribed. Missing doses may increase the chance of the virus becoming resistant to HIV medications.
  • Tipranavir can interact with a number of different medications (see Drug Interactions With Tipranavir).
  • Tipranavir is considered a pregnancy Category C medication. This means that it may not be safe for use during pregnancy, although the full risks are not known (see Aptivus and Pregnancy).
  • It is not known if tipranavir passes through breast milk. Therefore, if you are breastfeeding or plan to start, discuss this with your healthcare provider prior to taking the drug (see Aptivus and Breastfeeding). It is important to understand that the HIV virus can be transmitted through breast milk and that breastfeeding is usually not recommended in women with HIV or AIDS.

Tipranavir for HIV/AIDS

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