Drug Interactions With Tipranavir

Several medications can cause drug interactions with tipranavir, so tell your healthcare provider about all other medicines you are taking before starting HIV treatment. Medications that may interact with tipranavir include calcium channel blockers, vitamin E, arrhythmia medicines, and certain antifungals or antibiotics. Drug interactions with tipranavir can reduce the effectiveness of the medications or increase your risk of side effects.

 

Drug Interactions With Tipranavir: An Introduction

Tipranavir (Aptivus®) can potentially interact with several other medicines. Some of the medicines that may lead to tipranavir drug interactions include:
 
 
 
  • Certain antibiotics and antifungal medications, such as:
 
    • Clarithromycin (Biaxin®)
    • Fluconazole (Diflucan®)
    • Ketoconazole (Nizoral®)
    • Itraconazole (Sporanox®)
    • Rifabutin (Mycobutin®)
    • Rifampin (Rifadin®)
    • Voriconazole (Vfend®)
 
  • Certain benzodiazepines, such as:
 
 
  • Certain other protease inhibitors, such as:
 
 
 
 
  • Ergot medications, such as:
 
    • Bromocriptine (Parlodel®)
    • Dihydroergotamine (Migranal®)
    • Ergonovine
    • Ergotamine (Bellamine S®, Cafergot®, Ergomar®)
    • Methylergonovine (Methergine®)
    • Pergolide (Permax®)
 
 
    • Cyclosporine (Gengraf®, Neoral®, Sandimmune®)
    • Sirolimus (Rapamune®)
    • Tacrolimus (Prograf®)

 

  • Medications with anticoagulant or antiplatelet activity, such as:
     
    • Aspirin (Bayer® and others)
    • Clopidogrel (Plavix®)
    • Heparin or heparin-like products, such as:
 
      • Dalteparin (Fragmin®)
      • Enoxaparin (Lovenox®)
      • Tinzaparin (Innohep®)
 
    • Nonsteroidal anti-inflammatory drugs (NSAIDs), such as:
 
 
    • Warfarin (Coumadin®, Jantoven®)
 
 
 

 

(Drug Interactions With Tipranavir Continued: Page 2)
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Written by/reviewed by: Kristi Monson, PharmD; Arthur Schoenstadt, MD
Last reviewed by: Kristi Monson, PharmD;