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Drugs That React With Tipranavir

Tipranavir Interactions Explained

The following sections explain in detail the potentially negative interactions that can occur when tipranavir is combined with any of the drugs listed above.
 
Abacavir
Tipranavir can significantly decrease the level of abacavir in your blood, possibly making it less effective. Your healthcare provider may need to increase your abacavir dosage or recommend a different combination of medications.
 
Alfuzosin
Tipranavir should not be combined with alfuzosin, as this may increase the amount of alfuzosin in the blood to dangerous levels.
  
Antidepressants
Tipranavir can increase the level of many antidepressants in the blood, potentially increasing the risk of side effects. Your healthcare provider may need to decrease the dose of your antidepressant to prevent this interaction from occurring.
 
Arrhythmia Medications
Tipranavir should never be combined with amiodarone (Cordarone®, Pacerone®), flecainide (Tambocor™), propafenone (Rythmol®), or quinidine, due to the risk of dangerous reactions.
 
Bosentan
Tipranavir may increase the level of bosentan in your blood. Your healthcare provider may need to lower your bosentan dosage while you are taking tipranavir.
  
Calcium Channel Blockers
Tipranavir may affect the level of calcium channel blockers in your blood. Your healthcare provider may need to adjust the dose of your calcium channel blocker to prevent this interaction from occurring.
 
Certain Antibiotics or Antifungals
Combining tipranavir with certain antibiotics or antifungals may increase or decrease the level of both tipranavir and the antibiotic or antifungal in your blood. Check with your healthcare provider before taking tipranavir with any of these medications. It should never be combined with rifampin, since rifampin may make tipranavir less effective.

Tipranavir for HIV/AIDS

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