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Skyla Side Effects

Acne, vaginal irritation, and headaches are some of the common side effects of Skyla. Although most women tolerate this device well, it is possible to develop potentially serious problems. Contact your healthcare provider immediately if you experience problems like depression, pain during sex, or a missed menstrual period. Other, less-common side effects include migraines, hair loss, and oily skin.

An Introduction to Skyla Side Effects

As with any medicine, Skyla™ (levonorgestrel-releasing intrauterine system) can cause side effects. However, not all women who use this contraceptive will experience side effects. In fact, most women tolerate it quite well. If reactions do occur, in most cases, they are minor and either require no treatment or can easily be treated by you or your healthcare provider.
(This article covers many, but not all, of the possible side effects with Skyla. Your healthcare provider can discuss a more complete list with you.)

Common Side Effects of Skyla

Skyla has been studied extensively in clinical trials. In these studies, the side effects that occurred in a group of people using Skyla were carefully documented, so it was possible to see what side effects occurred and how often they occurred.
In these studies, the most common Skyla side effects included the following:
  • Vaginal irritation or infections, which could cause itching, discharge, and redness -- in up to 20.2 percent of women
  • Acne -- up to 13.6 percent
  • Cysts on the ovaries, which are usually painless and disappear on their own within a month or two -- up to 13.2 percent
  • Abdominal (stomach) pain -- up to 12.7 percent
  • Headache -- up to 12.4 percent
  • Painful menstrual periods -- up to 8.6 percent
  • Increased bleeding -- up to 7.8 percent
  • Nausea -- up to 5.5 percent
  • Pelvic pain -- up to 6.2 percent
  • Breast pain or discomfort -- up to 5.3 percent.
Other side effects, reported in 1.2 percent to 4.2 percent of women, included:
  • Vaginal discharge
  • Depression
  • Expulsion of Skyla (when it comes out on its own)
  • Migraine
  • Oily skin
  • Hair loss.
For the first three to six months you use Skyla, you may notice your menstrual periods are irregular. You may have more days of bleeding, heavier or lighter bleeding, and frequent spotting. After you have used Skyla for a while, this irregular bleeding and spotting will probably lessen.
Some women stop having menstrual periods altogether on Skyla. If you do not have a period for six weeks, you should contact your healthcare provider. He or she will check to make sure you're not pregnant.
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