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Skyla Drug Interactions

Skyla Drug Interactions Explained

The following sections explain in detail the potentially negative reactions that can occur when Skyla is combined with any of the drugs listed above.
 
Acitretin
Acitretin can reduce the effectiveness of progestin-only oral contraceptives (progestin-only birth control pills), which means they could fail to prevent pregnancy. It is unknown if acitretin interacts with other forms of progestin-only birth control, such as Skyla. However, there is a possibility that any progestin-only form of contraception could fail during acitretin treatment.
 
It is generally recommended that women of childbearing potential either abstain from sexual intercourse or use two reliable forms of birth control at least one month before starting acitretin, during acitretin treatment, and for three years after stopping the medication.
 
Aprepitant
Aprepitant can make hormonal contraceptives less effective. Alternative methods of birth control should be used by women of childbearing potential, both during aprepitant treatment and for at least one month after the last dose is taken.
 
Bosentan
Bosentan can make hormonal contraceptives less effective. To reduce the risk for unwanted pregnancy, women of childbearing potential who are taking bosentan should use other forms of birth control.
 
CYP 3A4 Inducer Medications
Certain enzymes in the liver known as CYP 3A4 enzymes help break down progestins, including levonorgestrel. Some other medications, known as CYP 3A4 inducers, can increase the activity of these enzymes. Combining progestin-containing birth control with one of these CYP 3A4 inducers may decrease the level of progestins in your blood, potentially making the birth control less effective.
 
It is not clear whether this interaction applies to Skyla. Skyla is inserted into the uterus, and is thought to primarily work in the uterus. However, it could be possible that a certain blood level of Skyla is also needed for it to work. To be safe, you may need to use a different form of birth control if you take a CYP 3A4 inducer and for at least one month after you stop taking the CYP 3A4 inducer.
 
CYP 3A4 Inhibitor Medications
Certain enzymes in the liver known as CYP 3A4 enzymes help break down progestins, including levonorgestrel. Some other medications known as CYP 3A4 inhibitors can decrease the activity of these enzymes. By decreasing the activity of the enzymes, CYP 3A4 inhibitors can increase progestin blood levels, which could increase the risk for progestin side effects. Talk to your healthcare provider about this potential interaction before using Skyla with a CYP 3A4 inhibitor.
 
Felbamate
Felbamate can decrease blood levels of progestin contraceptives, potentially making them less effective. Because Skyla contains levonorgestrel, a progestin hormone, this interaction may apply to it. Your healthcare provider may recommend a different form of birth control if you take felbamate.
 
Griseofulvin
Griseofulvin can make hormonal forms of birth control less effective. It is generally recommended that women use a non-hormonal birth control method during griseofulvin treatment. Talk to your healthcare provider before using griseofulvin in combination with Skyla.
 
Non-Nucleoside Reverse Transcriptase Inhibitors (NNRTI)
NNRTI medications can affect (increase or decrease, depending on the specific medication) blood levels of hormonal contraceptives. It is also important to note that hormonal forms of birth control do not protect against the transmission of HIV or other types of sexually transmitted infections. If you are being treated with a NNRTI, talk to your healthcare provider before using Skyla.
 
Protease Inhibitors
Protease inhibitors can affect (increase or decrease, depending on the specific medication) blood levels of hormonal contraceptives. It is also important to note that hormonal forms of birth control do not protect against the transmission of HIV or other types of sexually transmitted infections. If you are being treated with a protease inhibitor, talk to your healthcare provider before using Skyla.
 
Topiramate
Topiramate can decrease blood levels of levonorgestrel, potentially making it less effective. Talk to your healthcare provider before using these medications together.
 
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