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Drugs That Should Not Be Taken With Saquinavir

Proton Pump Inhibitors
Proton pump inhibitors (even non-prescription versions) can increase the level of saquinavir in your blood, possibly increasing the risk of side effects. Check with your healthcare provider before taking saquinavir with a proton pump inhibitor.
 
Ranitidine
Ranitidine (even non-prescription versions) can increase the level of saquinavir in your blood. Your healthcare provider may recommend that you take an alternative to ranitidine to prevent this interaction from occurring.
 
Salmeterol
Combining salmeterol with saquinavir may increase the risk of serious side effects of salmeterol, especially heart problems. Check with your healthcare provider before combining such medications. In general, these medications should not be combined.
  
Some Seizure Medications
Some seizure medications may decrease the level of saquinavir in your blood. Check with your healthcare provider before taking saquinavir with one of these medications.
 
Some Statin Medications
Saquinavir should never be combined with lovastatin or simvastatin, due to the risk of dangerous side effects. Because saquinavir may increase the level of atorvastatin or rosuvastatin in your blood, your healthcare provider may recommend a lower dosage of either of these statin medications.
 
St. John's Wort
Because St. John's wort can greatly reduce the level of saquinavir in your blood, these two substances should never be combined.
 
Tricyclic Antidepressants
Saquinavir may increase the level of tricyclic antidepressants in your blood. Your healthcare provider may need to lower the dose of your tricyclic antidepressant to prevent this interaction from occurring.

Saquinavir for HIV/AIDS

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