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Specific Medications That Interfere With Saquinavir

Saquinavir Interactions Explained

The following sections explain in detail the potentially serious but often manageable interactions that can occur when saquinavir is combined with any of the drugs listed above.
Saquinavir may increase the level of bosentan in your blood. Your healthcare provider may need to lower your bosentan dosage while you are taking saquinavir.
Calcium Channel Blockers
Saquinavir may increase the level of calcium channel blockers in your blood, possibly increasing the risk of side effects. Your healthcare provider may need to lower the dose of your calcium channel blocker.
Certain Antibiotics or Antifungals
Combining saquinavir with certain antibiotics or antifungals may increase or decrease the level of both saquinavir and the antibiotic or antifungal in your blood. Check with your healthcare provider before taking saquinavir with any of these medications. It should never be combined with rifampin, as it can make saquinavir less effective and may cause liver damage.
Certain Antipsychotics or Phenothiazines
Phenothiazine and certain antipsychotics may increase the risk of a dangerous irregular heart rhythm when combined with saquinavir. Check with your healthcare provider before combining such medications.
Certain Benzodiazepines
Saquinavir should not be combined with oral midazolam or triazolam, due to the risk of life-threatening reactions. If you take saquinavir with other benzodiazepine medications, your healthcare provider may recommend a lower dose of the benzodiazepines because saquinavir can increase the level of these medications in the blood.

Saquinavir for HIV/AIDS

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