Drug Interactions With Ritonavir

Antidepressants, blood pressure medications, and certain anxiety or sleep medications can cause drug interactions with ritonavir. While some interactions can decrease the effectiveness of ritonavir, others can increase your risk of developing serious side effects. Other medicines that may cause potentially dangerous drug interactions with ritonavir include disulfiram, alfuzosin, ergot medications, and metronidazole.

 

Drug Interactions With Ritonavir: An Introduction

Ritonavir (Norvir®) can potentially interact with several other medicines. Some of the medicines that may lead to drug interactions with ritonavir include:
 
 
    • Clarithromycin (Biaxin®)
    • Ketoconazole (Nizoral®)
    • Itraconazole (Sporanox®)
    • Rifabutin (Mycobutin®)
    • Rifampin (Rifadin®)
    • Voriconazole (Vfend®)
 
  • Certain anxiety or sleep medications, such as:
 
 
 
 
  • Ergot medications, such as:
 
    • Bromocriptine (Parlodel®)
    • Dihydroergotamine (Migranal®)
    • Ergonovine
    • Ergotamine (Bellamine S®, Cafergot®, Ergomar®)
    • Methylergonovine (Methergine®)
    • Pergolide (Permax®)
 
 
    • Cyclosporine (Gengraf®, Neoral®, Sandimmune®)
    • Sirolimus (Rapamune®)
    • Tacrolimus (Prograf®)
 
  • Meperidine (Demerol®)
  • Methadone (Dolophine®, Methadose®)
  • Methamphetamine (Desoxyn®)
  • Metronidazole (Flagyl®)
  • Other protease inhibitors, such as:
 
 
  • Pimozide (Orap®)
  • Propoxyphene medications (Darvocet®, Darvon®)
  • Quinine (Qualaquin™)
  • Seizure medications
  • Some statin medications, such as:
 
 
(Drug Interactions With Ritonavir Continued: Page 2)
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Written by/reviewed by: Kristi Monson, PharmD; Arthur Schoenstadt, MD
Last reviewed by: Kristi Monson, PharmD;