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Precautions and Warnings With Rilpivirine

People who have liver disease, kidney problems, or a history of mental illness may not be able to safely use rilpivirine. Also, make sure your healthcare provider is aware of any allergies you may have and whether you are pregnant or breastfeeding. Understanding the safety precautions and warnings with rilpivirine before beginning treatment can help ensure a safe and effective treatment.

What Should I Tell My Healthcare Provider Before Taking Rilpivirine?

Talk with your healthcare provider prior to taking rilpivirine (Edurant™) if you have:
  • Liver disease, such as liver failure, cirrhosis, or hepatitis
  • Kidney disease, such as kidney failure (renal failure)
  • A history of mental illness
  • Any allergies, including to foods, dyes, or preservatives.
Also, let your healthcare provider know if you are:
  • Pregnant or thinking of becoming pregnant
  • Breastfeeding.
You should also tell your healthcare provider about all other medications you are taking, including prescription and nonprescription medicines, vitamins, and herbal supplements.

Specific Rilpivirine Precautions and Warnings

Some warnings and precautions to be aware of prior to taking this medicine include the following:
  • In clinical studies, rilpivirine was associated with depression or other similar mood disorders. Make sure your healthcare provider knows if you have a history of mental illness, and be watchful for any undesired changes in mood or behavior.
  • Rilpivirine can change the distribution of fat on your body. You may gain fat in areas that are not typical for you, such as in the abdomen (stomach) or at the back of the neck (a "buffalo hump"), and may lose weight in other areas.
  • Rilpivirine is not a cure for HIV or AIDS. If you have HIV or AIDS, you should always use safe sex practices, regardless of whether you are taking medications.
  • As with all HIV medications, it is important that you take rilpivirine exactly as prescribed. Missing doses may increase the chance of the virus becoming resistant to HIV medications.
  • Rilpivirine is a pregnancy Category B medication. This means that it is probably safe for use during pregnancy, although the full risks are unknown (see Edurant and Pregnancy).
  • It is unknown if rilpivirine passes through breast milk. Therefore, if you are breastfeeding or plan to start, discuss this with your healthcare provider prior to taking the drug (see Edurant and Breastfeeding). It is important to understand that the HIV virus can be transmitted through breast milk and that breastfeeding is usually not recommended in women with HIV or AIDS.

Rilpivirine Drug Information

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