Drug Interactions With Rilpivirine

There are a number of medications that may cause negative drug interactions with rilpivirine, including methadone, certain seizure medicines, and antibiotics or antifungals. Some of these reactions can decrease the absorption of rilpivirine into the bloodstream, significantly reducing its effectiveness. Before starting treatment with this HIV medicine, let your healthcare provider know about all other medications, vitamins, and supplements you are taking.

An Overview of Rilpivirine Interactions

 Rilpivirine (Edurant™) can react with several other medicines. Some of these drugs that may lead to rilpivirine interactions include:
 
  • Antacids, such as Tums® or Maalox®
  • Certain antibiotics and antifungal medications, such as:
 
 
  • Certain seizure medications, such as:
 
 
 
 
  • Methadone (Dolophine®, Methadose®)
  • Other medications that cause a change in the heart rhythm known as QT prolongation (see QT-Prolonging Medications for a list)
  • Other non-nucleoside reverse transcriptase inhibitor (NNRTI) HIV medications, such as:
 
 
  • Proton pump inhibitors (PPIs), such as:
 
 
  • Rifabutin (Mycobutin®), rifampin (Rifadin®), or rifapentine (Priftin®)
  • St. John's wort.
 
Drug Interactions With Rilpivirine Article Continues on Next Page >
Written by/reviewed by: Kristi Monson, PharmD
Last reviewed by: Kristi Monson, PharmD
 
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