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More Medicines That React With Rilpivirine

Proton Pump Inhibitors (PPIs)
Rilpivirine should never be combined with PPIs, as these medications may significantly reduce the effectiveness of rilpivirine.
 
Other QT Prolongers
Several medications cause a change in the heart rhythm, known as QT prolongation, to varying degrees. If severe enough, this change can lead to a life-threatening arrhythmia known as torsades de pointes (TDP). Because rilpivirine can cause QT prolongation (especially at higher-than-recommended dosages), it should be used with caution and extra monitoring when combined with other QT-prolonging drugs.
 
Other NNRTIs
Rilpivirine is an NNRTI and should not be combined with other NNRTIs.
 
Rifabutin, Rifampin, or Rifapentine
Rilpivirine should never be combined with rifabutin, rifampin, or rifapentine, as these medications may significantly decrease the effectiveness of rilpivirine.
 
St. John's Wort
Because St. John's wort can significantly reduce the level of rilpivirine in your blood, these medications should never be taken together.
 

Final Thoughts

It is possible that not all rilpivirine drug interactions were discussed in this article. Therefore, you should talk with your pharmacist or healthcare provider about any specific interactions that may apply to you.

Rilpivirine Drug Information

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