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Specific Drugs That Interfere With Rilpivirine

Drug Interactions With Rilpivirine Explained

The following sections explain in detail the potentially negative reactions that can occur when rilpivirine is combined with any of the drugs listed above.
 
Antacids
Antacids can decrease the absorption of rilpivirine in the body, causing it to be less effective. Make sure to take antacid medications at least two hours before or three hours after your dose of rilpivirine.
 
Certain Antibiotics or Antifungals
Combining rilpivirine with certain antibiotics or antifungals may increase the level of rilpivirine (and could decrease the level of some antifungals) in your blood. Check with your healthcare provider before taking rilpivirine with any of these medications.
 
Certain Seizure Medications
Rilpivirine should never be combined with carbamazepine, oxcarbazepine, phenobarbital, or phenytoin, as these medications may significantly reduce the effectiveness of rilpivirine.
 
Dexamethasone
Rilpivirine should never be combined with more than a single dose of dexamethasone, as it may significantly reduce the effectiveness of rilpivirine. A single, one-time dose of dexamethasone is acceptable.
 
H2 Blockers
H2 blockers can decrease the absorption of rilpivirine, making it less effective. If you absolutely must take an H2 blocker, take it at least 12 hours before or four hours after a dose of rilpivirine. With this type of a dosing schedule, using a twice-a-day H2 blocker is probably not possible.
 
Methadone
Rilpivirine can decrease the level of methadone in your blood, perhaps making it less effective. Your healthcare provider may need to increase your methadone dosage.

Rilpivirine Drug Information

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