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Raltegravir Dosing

Raltegravir dosing guidelines vary depending on whether you are taking other medications. For example, the dose for treating adults who are not taking rifampin is one 400-mg tablet, taken twice daily. You should make sure that you do not miss your raltegravir doses, as doing so can cause the HIV virus to become resistant to the drug.

Raltegravir Dosing: An Introduction

There is only one standard dose of raltegravir (Isentress®). As always, do not adjust your dose unless your healthcare provider specifically instructs you to do so.

Raltegravir Dosing for Adults

The recommended dose of raltegravir for treating adults with HIV or AIDS is raltegravir 400 mg twice daily. For people taking rifampin (Rifadin®), the recommended dosage for raltegravir is 800 mg twice daily since rifampin decreases the level of raltegravir in the blood.
The regular tablets (not the chewable tablets) should be used for adults. Notably, the regular tablets and the chewable tablets are not bioequivalent. This means that four 100-mg chewable tablets will not provide the same dosage as one 400-mg regular tablet due to differences in absorption. As a result, the two forms are not interchangeable.

Raltegravir Dosing for Children and Teens

The recommended dose of raltegravir for treating adolescents weighing at least 55 pounds with HIV or AIDS is 400 mg twice daily, using the regular tablets. If the child is unable to swallow the tablet, the chewable tablet may be used and will be dosed according to the child's weight.
For children at least four weeks of age and weighing 6.6 to 24 pounds, the recommended dosage is weight-based using the oral suspension twice daily. Children weighing 24 to 44 pounds may be given either the oral suspension or the chewable tablets (again, using weight-based dosing). Children who weigh 44 to 55 pounds should be given the chewable tablet (1.5 tablets of the 100-mg tablet). For weight-based dosing, the child's healthcare provider will calculate an appropriate amount based on the child's current weight.

Raltegravir Drug Information

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