Drug Interactions With Raltegravir

Drug interactions with raltegravir may occur if the HIV medication is taken with certain other drugs, such as atazanavir, phenobarbital, and phenytoin. These interactions can alter the level of raltegravir in your blood, possibly making it less effective. To avoid these problems, be sure to talk to your healthcare provider about drug interactions with raltegravir that may apply to you.

 

Drug Interactions With Raltegravir: An Overview

Raltegravir (Isentress™) can potentially interact with several other medicines. Some of the medicines that may lead to drug interactions with raltegravir include:
 

Raltegravir Interactions Explained

The following sections explain in detail the potentially negative interactions that can occur when raltegravir is combined with any of the drugs listed above.
 
Atazanavir
Atazanavir increases the level of raltegravir in your blood. However, this interaction usually does not cause any problems. Nevertheless, check with your healthcare provider before combining these two medications.
 
Phenobarbital
Theoretically, phenobarbital may decrease the level of raltegravir in your blood, making it less effective. However, this interaction has not been adequately studied, so it is difficult to predict exactly how these medications will affect each other. Check with your healthcare provider before taking them together.
 
Phenytoin
Theoretically, phenytoin may decrease the level of raltegravir in your blood, making it less effective. However, this interaction has not been adequately studied, so it is difficult to predict exactly how these medications will interact. Check with your healthcare provider before taking them together.
(Drug Interactions With Raltegravir Continued: Page 2)
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Written by/reviewed by: Kristi Monson, PharmD; Arthur Schoenstadt, MD
Last reviewed by: Kristi Monson, PharmD;