Drug Interactions With Raltegravir

Problems may occur if raltegravir is taken with certain other medications, such as atazanavir, phenobarbital, and phenytoin. These interactions can alter the level of raltegravir in your blood, possibly making it less effective. To avoid these problems, be sure to talk to your healthcare provider about any raltegravir drug interactions that may apply to you.

Raltegravir Drug Information

Drug Interactions With Raltegravir: An Overview

Raltegravir (Isentress^™) can potentially interact with several other medicines. Some of the medicines that may lead to drug interactions with raltegravir include:

Atazanavir (Reyataz^®)
Efavirenz (Sustiva^®)
Etravirine (Intelence^™)
H2 blockers, such as:
- Cimetidine (Tagamet^®)
- Famotidine (Pepcid^®)
- Nizatidine (Axid^®)
- Ranitidine (Zantac^®)

Phenobarbital (Luminal^®)
Phenytoin (Dilantin^®)
Proton pump inhibitors (PPIs), including:
- Dexlansoprazole (Kapidex^™)
- Esomeprazole (Nexium^®)
- Lansoprazole (Prevacid^®)
- Omeprazole (Prilosec^®)
- Pantoprazole (Protonix^®)
- Rabeprazole (AcipHex^®)

Rifampin (Rifadin^®)

Tipranavir (Aptivus^®) combined with ritonavir (Norvir^®).

Raltegravir Drug Interactions Explained

The following sections explain in detail the potentially negative interactions that can occur when raltegravir is combined with any of the drugs listed above.

(Drug Interactions With Raltegravir Continued: Page 2)