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Will My Medicines Interfere With Raltegravir?

Phenytoin
Theoretically, phenytoin may decrease the level of raltegravir in your blood, making it less effective. However, this interaction has not been adequately studied, so it is difficult to predict exactly how these medications will interact. Check with your healthcare provider before taking them together.
 
Proton Pump Inhibitors (PPIS)
PPIs may increase the absorption of raltegravir into your system. However, no dosage adjustment is recommended.
  
Rifampin
Rifampin decreases the level of raltegravir in the blood, possibly making it less effective. If you take rifampin, higher raltegravir dosing is recommended.
Tipranavir Combined With Ritonavir
Taking raltegravir with tipranavir and ritonavir can lower the level of raltegravir in your blood. However, studies have shown that these medications can usually be combined without making raltegravir less effective.
 

Final Thoughts

It is possible that not all raltegravir drug interactions were discussed in this article. Therefore, you should talk with your pharmacist or healthcare provider about the specific interactions that may apply to you.
 

Raltegravir Drug Information

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