Drug Interactions With Raltegravir

Atazanavir
Atazanavir increases the level of raltegravir in your blood. However, this interaction usually does not cause any problems. Nevertheless, check with your healthcare provider before combining these two medications.
 
Efavirenz
Efavirenz may decrease the level of raltegravir in your blood. However, it is unknown at this time if the decrease is significant enough to warrant any dose changes. Your healthcare provider will take this into account when prescribing these medications.
 
Etravirine
Etravirine may decrease the level of raltegravir in your blood. However, it is unknown at this time if the decrease is significant enough to warrant any dose changes. Your healthcare provider will take this into account when prescribing these medications.
 
H2 Blockers
H2 blockers may increase the absorption of raltegravir into your system. However, no dosage adjustment is recommended.
  
Phenobarbital
Theoretically, phenobarbital may decrease the level of raltegravir in your blood, making it less effective. However, this interaction has not been adequately studied, so it is difficult to predict exactly how these medications will affect each other. Check with your healthcare provider before taking them together.
 
Phenytoin
Theoretically, phenytoin may decrease the level of raltegravir in your blood, making it less effective. However, this interaction has not been adequately studied, so it is difficult to predict exactly how these medications will interact. Check with your healthcare provider before taking them together.
 
Proton Pump Inhibitors (PPIS)
PPIs may increase the absorption of raltegravir into your system. However, no dosage adjustment is recommended.
  
Rifampin
Rifampin decreases the level of raltegravir in the blood, possibly making it less effective. If you take rifampin, higher raltegravir dosing is recommended.
 
Tipranavir Combined With Ritonavir
Taking raltegravir with tipranavir and ritonavir can lower the level of raltegravir in your blood. However, studies have shown that these medications can usually be combined without making raltegravir less effective.
 
(Drug Interactions With Raltegravir Continued: Page 3)
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Written by/reviewed by: Kristi Monson, PharmD; Arthur Schoenstadt, MD
Last reviewed by: Kristi Monson, PharmD;
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