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Drugs That Can React With Raltegravir

Raltegravir Drug Interactions Explained

The following sections explain in detail the potentially negative interactions that can occur when raltegravir is combined with any of the drugs listed above.
 
Antacids
Antacids, especially those that contain aluminum or magnesium, bind to raltegravir in the digestive tract, preventing it from being absorbed, which makes it less effective. This also occurs with calcium-containing antacids, but to a much lesser extent. It's best to avoid taking magnesium- or aluminum-containing antacids when you are on raltegravir. Calcium-containing antacids are probably fine.
 
Atazanavir
Atazanavir increases the level of raltegravir in your blood. However, this interaction usually does not cause any problems. Nevertheless, check with your healthcare provider before combining these two medications.
 
Efavirenz
Efavirenz may decrease the level of raltegravir in your blood. However, it is unknown at this time if the decrease is significant enough to warrant any dose changes. Your healthcare provider will take this into account when prescribing these medications.
 
Etravirine
Etravirine may decrease the level of raltegravir in your blood. However, it is unknown at this time if the decrease is significant enough to warrant any dose changes. Your healthcare provider will take this into account when prescribing these medications.
 
H2 Blockers
H2 blockers may increase the absorption of raltegravir into your system. However, no dosage adjustment is recommended.
  
Phenobarbital
Theoretically, phenobarbital may decrease the level of raltegravir in your blood, making it less effective. However, this interaction has not been adequately studied, so it is difficult to predict exactly how these medications will affect each other. Check with your healthcare provider before taking them together.

Raltegravir Drug Information

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