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Drugs That Interfere With Ortho-Cyclen

Ortho-Cyclen Interactions Explained

The following sections explain in detail the potentially negative interactions that can occur when Ortho-Cyclen is combined with any of the drugs listed above.
 
Aminoglutethimide (Cytadren)
Taking Ortho-Cyclen and aminoglutethimide together increases the risk of pregnancy. You may need to use a backup method of contraception (such as condoms). Do not use these medications together without checking with your healthcare provider first.
 
Antibiotics
There have been reports of accidental pregnancy occurring in women taking birth control pills together with certain antibiotics. There is disagreement as to how significant and severe these interactions may be. Some antibiotics are more likely to cause problems than others. Ask your healthcare provider if you need a backup method of contraception any time you take an antibiotic.
 
Aprepitant (Emend)
Aprepitant may make Ortho-Cyclen less effective, perhaps increasing your chance of pregnancy. Talk with your healthcare provider before using these medications together. You may need to use a backup method of contraception.
 
Atorvastatin (Lipitor)
Atorvastatin may increase the level of Ortho-Cyclen in your blood, which may increase your risk of Ortho-Cyclen side effects. Check with your healthcare provider before taking these medications together.
 
Barbiturates
Barbiturates may cause your body to metabolize the hormones in Ortho-Cyclen too quickly, increasing your risk of pregnancy. Ask your healthcare provider if you should use a different method of contraception while taking a barbiturate.
 
Cyclosporine (Gengraf, Neoral, Sandimmune)
Ortho-Cyclen may increase the level of cyclosporine in your blood, increasing the chance of side effects of cyclosporine. Talk with your healthcare provider before taking these medications together. Your cyclosporine dose may need to be reduced, or you may need to switch to a different method of contraception.
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