Cyclosporine (Gengraf, Neoral, Sandimmune)
Ogestrel may increase the level of cyclosporine in your blood, possibly increasing the chance of side effects of cyclosporine. Talk with your healthcare provider before taking these medications together. You may need a lower cyclosporine dose, or you may need to switch to a different method of contraception.
Modafinil (Provigil)
Modafinil can make Ogestrel less effective, possibly increasing your risk of pregnancy. Talk with your healthcare provider, as you may need to use a backup method of contraception.
Protease Inhibitors
Using Ogestrel with a protease inhibitor may increase your risk of pregnancy and can make the protease inhibitor less effective. Talk with your healthcare provider before combining these medications.
Selegiline (Eldepryl, Emsam, Zelapar)
The hormones in Ogestrel may increase the level of
selegiline in your blood, perhaps increasing your risk of side effects. Your healthcare provider may need to lower your
selegiline dosage or may recommend an alternate form of contraception.
Some Seizure Medications
Some
seizure medications may cause your body to metabolize the hormones in Ogestrel too quickly, potentially increasing your risk of pregnancy. Ask your healthcare provider if you should use a different method of contraception while taking a
seizure medication.
St. John's Wort
St. John's wort (a commonly used herbal supplement) may decrease the effectiveness of Ogestrel, possibly increasing the chance of pregnancy. Although there is some disagreement as to how significant this interaction may be, you should not take St. John's wort while using Ogestrel until more information is available.
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