Drugs That Interact With Nelfinavir
Nelfinavir Interactions Explained
The following sections explain in detail the potentially negative interactions that can occur when nelfinavir is combined with any of the drugs listed above.
Combining nelfinavir with certain antibiotics may increase or decrease the level of both nelfinavir and the antibiotic in your blood. Check with your healthcare provider before taking nelfinavir with any of these medications. Nelfinavir should never be combined with rifampin, since rifampin may make nelfinavir less effective.
Certain Arrhythmia Medications
Nelfinavir should never be combined with amiodarone or quinidine, due to the risk of life-threatening reactions.
Nelfinavir should not be combined with triazolam or oral midazolam, due to the risk of life-threatening reactions.
Nelfinavir should not be combined with cisapride, due to the risk of dangerous side effects.
Combining delavirdine with nelfinavir increases the level of nelfinavir in your blood and decreases the level of delavirdine in your blood. Your healthcare provider may need to adjust your dose of these medications or recommend a different combination of medications.
Didanosine oral solution (but not didanosine capsules) can decrease absorption of nelfinavir into your body, perhaps making it less effective. Also, didanosine must be taken on an empty stomach and nelfinavir must be taken with a meal. Make sure to take didanosine (on an empty stomach) at least one hour before or two hours after nelfinavir (with a meal).