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MetroGel-Vaginal Warnings and Precautions

If your healthcare provider recommends treatment with MetroGel-Vaginal, make sure he or she is aware if you have a history of low blood cell counts or any allergies. Other important information to discuss with your healthcare provider is whether you are taking any other medications, as there are some warnings for potential drug interactions. Safety precautions with MetroGel-Vaginal also apply to women who are pregnant or breastfeeding.

What Should I Tell My Healthcare Provider?

You should talk with your healthcare provider prior to using MetroGel-Vaginal® (metronidazole vaginal gel) if you:
  • Have any allergies, including to medications, foods, dyes, or preservatives
  • Have a history of low blood cell counts
  • Have liver disease, such as hepatitis, liver failure, or cirrhosis
  • Are pregnant or thinking of becoming pregnant
  • Are breastfeeding.
You should also tell your healthcare provider about all other medications you are taking, including prescription and nonprescription medicines, vitamins, and herbal supplements.

Specific Precautions and Warnings With MetroGel-Vaginal

Some warnings and precautions to be aware of prior to using this medication include the following:
  • MetroGel-Vaginal is for vaginal use only. Do not swallow it, and make sure to keep it out of the eyes. If you accidentally get some of the gel in your eyes, flush your eyes with large amounts of cool tap water.
  • In rare cases, some people have had seizures or developed peripheral neuropathy due to oral or intravenous (IV) metronidazole, the active ingredient in MetroGel-Vaginal. Thus, such problems are at least theoretically possible with MetroGel-Vaginal. Signs of peripheral neuropathy typically include unusual sensations, such as burning, tingling, or pricking in the extremities (the hands, lower legs, and feet). Let your healthcare provider know if you develop any such problems.
  • Make sure your healthcare provider knows if you have (or have ever had) low blood cell counts, such as low white blood cells, low platelets, or anemia. Although it is probably quite unlikely, it is possible that MetroGel-Vaginal could make such problems worse.
  • Although MetroGel-Vaginal is applied vaginally, some of the medication is absorbed into the bloodstream. If you have liver disease, your body will clear the medication from the bloodstream more slowly, perhaps leading to increased levels of the drug.
  • Do not have sex while you are using this product.
  • Be aware that up to 10 percent of women develop vaginal yeast infections during or immediately after treatment with MetroGel-Vaginal. Such infections need to be treated, as this drug is not effective against yeast infections.
  • The active ingredient in MetroGel-Vaginal passes through breast milk. Therefore, if you are breastfeeding a child or plan to start, check with your healthcare provider (or your child's healthcare provider) before using this product (see MetroGel-Vaginal and Breastfeeding).
  • MetroGel-Vaginal is a pregnancy Category B medication, which means that it is probably safe for use during pregnancy, although the full risks are currently unknown (see MetroGel-Vaginal and Pregnancy for more information).
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MetroGel-Vaginal Information

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