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Geriatric and Off-Label Indications for Medroxyprogesterone

Can Older Adults Use It?

Medroxyprogesterone is indicated for use in postmenopausal women who are taking estrogen. The combination of estrogen plus progestin may be used short-term for intolerable symptoms of menopause. However, it is recommended that hormone therapy be used for the shortest time possible due to the potential for serious side effects with long-term use, such as:
Studies show that older women seem to have a greater risk for these side effects. Older women who are experiencing symptoms of menopause should be evaluated by their healthcare provider every three to six months to determine if they still need hormone treatment.

Is Medroxyprogesterone Used for Off-Label Reasons?

On occasion, a healthcare provider may recommend this drug for something other than the uses discussed in this article. This is known as an "off-label" use. Some forms of medroxyprogesterone are used off-label for the following reasons:
  • Treating endometriosis
  • Managing symptoms of certain types of advanced cancer
  • Relieving symptoms of menopause
  • Reducing sexual aggression in men with dementia.
Medroxyprogesterone should not be used off-label to prevent heart disease or dementia. It does not protect against these conditions. It should also not be used off-label to promote youthfulness, or as hormone replacement in the absence of a medical need.
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