Medroxyprogesterone Warnings and Precautions

Although generally safe and effective, medroxyprogesterone is not suitable for everyone. Warnings and precautions extend to a number of people, including those with heart disease, breast cancer, or high blood pressure. Women who use medroxyprogesterone should receive regular screening and monitoring. Because the injection form of this medication can cause bone loss, it should not be used for longer than two years unless absolutely necessary.

Medroxyprogesterone Drug Information

What Should I Tell My Healthcare Provider?

Talk with your healthcare provider prior to using

medroxyprogesterone (Provera^®, Depo-Provera^®, depo-subQ Provera 104^®) if you have:

Unexplained vaginal bleeding
Breast cancer or have ever had breast cancer
An abnormal mammogram, lumps in your breasts, or bleeding from your nipples
Estrogen- or progestin-dependent cancer
Had a stroke or heart attack in the past year
A history of blood clots
Heart disease
High blood pressure (hypertension)
High cholesterol (hypercholesterolemia)
An underactive thyroid (hypothyroidism)
Liver disease, such as hepatitis, cirrhosis, or liver failure
Kidney disease, such as kidney failure (renal failure)
Migraine headaches
Asthma
Seizures or epilepsy
Endometriosis
Systemic lupus erythematosus (SLE or lupus)
Low blood calcium levels
Diabetes
Depression
Osteoporosis or a history of fracturing a bone, or have a family history of osteoporosis
An alcohol problem or drink a lot of alcohol
Anorexia nervosa (an eating disorder)
Plans to have surgery
Any allergies, including to foods, dyes, or preservatives.

Also, let your healthcare provider know if you:

Smoke cigarettes or use tobacco products
Are pregnant or thinking of becoming pregnant (see Medroxyprogesterone and Pregnancy)
Are breastfeeding (see Medroxyprogesterone and Breastfeeding).

Make sure to tell your healthcare provider about any medications you are taking, including prescription and nonprescription medicines, vitamins, and herbal supplements.

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