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Ensuring Your Safety With Medroxyprogesterone

Specific Precautions and Warnings With Medroxyprogesterone

Some warnings and precautions to be aware of prior to using this medication include the following:
  • Studies have shown that using estrogen in combination with medroxyprogesterone (known as combination hormone therapy, or combination HT) increases the risk for heart attacks, stroke, breast cancer, dementia, and blood clots. Because of these risks, combination HT should only be used at the lowest effective dose for the shortest time necessary. Talk to your healthcare provider every three to six months to determine if you still need HT.
  • Combination HT does not protect against heart disease or dementia, and should not be used to prevent heart disease, dementia, stroke, or a heart attack.
  • Medroxyprogesterone injection can cause bone loss, which may increase your risk for osteoporosis and fractures. Your bones may not return to normal even after stopping the medication. The longer you use medroxyprogesterone injection, the greater its effects on bone. Therefore, the medication should not be used for longer than two years unless absolutely necessary.
  • Let your healthcare provider know if you experience abnormal vaginal bleeding, such as heavy bleeding, bleeding between periods, or bleeding after menopause, while using this medication. These could be signs of a serious problem.
  • Using tobacco; being overweight; or having hypertension (high blood pressure), high cholesterol, diabetes, or lupus can increase your risk for heart disease, stroke, or blood clots. Talk to your healthcare provider about ways you can appropriately manage these conditions before starting medroxyprogesterone to help lower your risk.
  • Women who use this medicine should receive regular screening and monitoring, including routine blood pressure checks, breast exams, and mammograms. You may need to be followed more closely if you have ever had an abnormal mammogram or breast lumps, or have a family history of breast cancer. Talk to your healthcare provider about how frequently you should be monitored while using this medicine.
  • Medroxyprogesterone can increase the risk for strokes and blood clots in your arms, legs, lungs, and eyes. Seek immediate medical attention if you experience signs of a stroke or blood clot, such as changes in your vision or speech; shortness of breath; sudden chest pain; or weakness, swelling, or pain in an arm or leg.
  • Medroxyprogesterone can increase blood pressure and cholesterol levels, and may cause impaired glucose tolerance (sometimes referred to as "prediabetes"). Your healthcare provider will likely monitor you for these problems.
  • Contact your healthcare provider right away if you experience yellowing of the whites of the eyes or skin (jaundice), which could be signs of liver problems. If you have had jaundice in the past due to estrogen use or pregnancy, your healthcare provider may choose to monitor you more closely if you take medroxyprogesterone with an estrogen.
  • This drug can cause fluid retention, which may be a problem for people with certain medical conditions, such as congestive heart failure (CHF), kidney disease, asthma, seizure disorder, or migraines. Your healthcare provider may need to monitor you more closely if you have a condition that could be affected by fluid retention.
  • Medroxyprogesterone can make certain chronic medical conditions worse, including asthma, diabetes, epilepsy, seizures, migraines, an underactive thyroid (hypothyroid), and lupus. It should be used with caution in people with low blood calcium levels (hypocalcemia). Your healthcare provider may need to follow you more closely if you have one of these conditions.
  • If you are using medroxyprogesterone injection to prevent pregnancy, you should know it does not protect against HIV or other sexually transmitted diseases (STDs). You will need another form of contraception to protect yourself from STDs.
  • Medroxyprogesterone may react with a number of other medications (see Medroxyprogesterone Drug Interactions for more information).
  • This medicine passes through breast milk. Therefore, if you are breastfeeding or plan to start, discuss this with your healthcare provider prior to starting the drug (see Medroxyprogesterone and Breastfeeding).
  • Medroxyprogesterone is considered a pregnancy Category X medication. This means it should not be used in pregnant women (see Medroxyprogesterone and Pregnancy).
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