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Medroxyprogesterone Side Effects

Some side effects to watch out for during treatment with medroxyprogesterone include headache, breast tenderness, and lack of menstruation (amenorrhea). While most reactions are minor and require little or no treatment, some serious problems can occur and should be reported immediately. These include migraine headaches, sudden vision loss, and yellowing of the skin.

An Introduction to Medroxyprogesterone Side Effects

Just like any medicine, medroxyprogesterone (Provera®, Depo-Provera®, depo-subQ Provera 104®) can cause side effects. However, not everyone who uses the medication will have problems. In fact, most people tolerate it quite well. If reactions do occur, in most cases, they are minor and either require no treatment or are treated easily by you or your healthcare provider.
(This article covers many, but not all, of the possible side effects with medroxyprogesterone. Your healthcare provider can discuss a more complete list with you.)

Serious Side Effects of Medroxyprogesterone

Some medroxyprogesterone side effects are potentially serious and should be reported immediately to your healthcare provider. These include but are not limited to:
    • Vision or speech changes
    • Weakness or numbness in an arm or leg
    • Severe headache
  • Signs of a blood clot in the lung, such as:
    • Shortness of breath
    • Sudden chest pain
    • Coughing up blood
  • Signs of a blood clot in the leg, such as severe pain or swelling of the calf
  • Signs of a blood clot in the eye, such as sudden vision loss or vision changes
  • Yellowing of the skin, whites of the eyes, or nails (jaundice)
  • Chest pain or heaviness, which could be signs of a heart attack
  • Persistent abnormal menstrual periods or unusual or heavy vaginal bleeding
  • High blood glucose levels
  • Breast lumps
  • High blood pressure (hypertension)
  • Signs of an allergic reaction, such as:
    • Hives
    • Itching
    • Unexplained swelling of the mouth or throat
    • Wheezing or difficulty breathing or swallowing.
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