Medroxyprogesterone Overdose

Taking an overdose of medroxyprogesterone (Provera, Depo-Provera, depo-subQ Provera 104) is unlikely to cause serious problems. In fact, it's possible that no symptoms would occur in the case of a mild overdose. If symptoms do occur, they may include things like fatigue, headache, nausea, and vomiting. Treatment would likely involve supportive care, such as close monitoring of the kidneys and liver.

Can You Take Too Much Medroxyprogesterone?

Medroxyprogesterone (Provera®, Depo-Provera®, depo-subQ Provera 104®) is a synthetic progestin that is similar to progesterone. The oral form of the medicine (Provera) is used to treat irregular vaginal bleeding and amenorrhea (absence of periods). It is also used in hormone therapy to reduce the risk of uterine cancer in women taking estrogen.
 
Medroxyprogesterone is also used as an injectable form of birth control (Depo-Provera and depo-subQ Provera 104).
 
As with most medications, it is possible to take too much medroxyprogesterone. In most cases, an overdose is not considered dangerous. However, the specific effects of an overdose with medroxyprogesterone may vary, depending on a number of factors, including how much medroxyprogesterone was taken and whether it was taken with any other medications.
 
If you happen to overdose on this medication, seek immediate medical attention.
 

Effects of an Overdose

In many cases, it is possible that no symptoms will occur, especially if the overdose is mild.
 Symptoms are more likely to occur with higher doses or if the medication is given over an extended period. If medroxyprogesterone overdose symptoms do occur, they may include:
 
  • Nausea
  • Vomiting
  • Breast tenderness or pain
  • Dizziness
  • Abdominal pain (stomach pain)
  • Fatigue and drowsiness
  • Vaginal bleeding
  • Headache
  • Yellowing of the skin or the whites of the eyes (jaundice)
  • Irregular menstruation, such as spotting or heavier or lighter periods
  • Bloating
  • Depression
  • Decreased libido (sex drive).
     
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Written by/reviewed by: Susan Lakey, PharmD, MPH
Last reviewed by: Kristi Monson, PharmD
 
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