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Medroxyprogesterone Drug Interactions

Using medroxyprogesterone with certain medications, including Epitol, Kenalog, and Norvir, can lead to drug interactions. These reactions can increase your risk of side effects (such as loss of bone density) and, in some cases, potentially increase your risk of unintentional pregnancy. If drug interactions are a concern, your healthcare provider may need to adjust the dosage of your medications.

An Overview of Interactions With Medroxyprogesterone

Medroxyprogesterone (Provera®, Depo-Provera®, depo-subQ Provera 104®) may react with a number of other medications. Some of the drugs that may lead to interactions with medroxyprogesterone include but are not limited to:
  • Corticosteroids, such as:
    • Betamethasone (Celestone®)
    • Cortisone
    • Dexamethasone (Decadron®)
    • Fludrocortisone (Florinef®)
    • Hydrocortisone (Cortef®)
    • Methylprednisolone (Depo-Medrol®, Medrol®)
    • Prednisolone (Orapred®, Pediapred®)
    • Prednisone
    • Triamcinolone (Kenalog®, Aristospan®)
  • Tranexamic acid (Cyklokapron®, Lysteda®).
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Medroxyprogesterone Drug Information

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