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More Products That Interfere With Medroxyprogesterone

CYP 3A4 Inducer Medications
The body breaks down the hormones in medroxyprogesterone using enzymes in the liver known as CYP 3A4 enzymes. Medications known as CYP 3A4 inducers can increase the activity of these enzymes. Combining medroxyprogesterone with one of these drugs may decrease the level of medroxyprogesterone in your body, possibly making it less effective.
Griseofulvin may decrease the effectiveness of combination birth control pills (pills that contain estrogen and progestin). It is unknown if griseofulvin also affects injectable medroxyprogesterone. However, if you are using medroxyprogesterone to prevent pregnancy, you may want to use a backup method of birth control while taking griseofulvin, just to be safe.
Protease Inhibitors
Protease inhibitors can increase or decrease the level of medroxyprogesterone in the body, which could increase your risk for side effects or make the medication less effective. Check with your healthcare provider before combining medroxyprogesterone with a protease inhibitor.
Retinoids may decrease the effectiveness of progestin-only birth control pills. It is unknown if retinoids affect injectable medroxyprogesterone in the same way. If you are using medroxyprogesterone for birth control, talk to your healthcare provider about this potential drug interaction. You may need to use a different method of birth control.
Thyroid Medications
If you take medications for an underactive thyroid (hypothyroidism), your healthcare provider may need to increase your dose after you start taking medroxyprogesterone. Your healthcare provider will monitor you and adjust the dose of your thyroid treatment if needed.
Tranexamic Acid
Both tranexamic acid and hormonal contraceptives, such as injectable medroxyprogesterone, can increase the risk of blood clots. Thus, taking these medications together may increase your risk for a blood clot even more than using either medicine alone. Talk to your healthcare provider about this potential interaction before taking these drugs together.
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Medroxyprogesterone Drug Information

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