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Medroxyprogesterone Dosage

For the prevention of pregnancy, the recommended dose of medroxyprogesterone is one injection every three months. However, this medication comes in both tablet and injection form, and many factors will influence what form and strength your healthcare provider recommends. For example, with the oral form, one tablet is meant to be taken daily for 5 to 14 days, depending on the condition being treated.

An Introduction to Your Dosage of Medroxyprogesterone

The dose of medroxyprogesterone (Provera®, Depo-Provera®, depo-subQ Provera 104®) your healthcare provider recommends will vary, depending on a number of factors, including:
  • The particular medroxyprogesterone product you are using
  • Why you are taking the medicine
  • How you respond to it.
As is always the case, do not adjust your dose unless your healthcare provider specifically tells you to do so.

Medroxyprogesterone Oral Dosing Guidelines

The standard dosage of medroxyprogesterone (Provera) for treating amenorrhea (absence of menstrual periods) or abnormal vaginal bleeding is either 5 mg or 10 mg daily for 5 to 10 days. When used to treat abnormal vaginal bleeding, medroxyprogesterone should be started on day 16 or 21 of the menstrual cycle. When used for amenorrhea, treatment can be started at any time. Vaginal bleeding normally occurs three to seven days after the medication is stopped.
The standard medroxyprogesterone dose for preventing endometrial hyperplasia (an overgrowth of the lining of the uterus) in postmenopausal women taking 0.625 mg of estrogen is 5 mg or 10 mg daily for 12 to 14 days, starting on day 1 or day 16 of the menstrual cycle.
This dosing only applies to women who have not had a hysterectomy (women who still have a uterus). Women who no longer have a uterus (who have had a hysterectomy) do not need medroxyprogesterone treatment.
It is typically recommended that women use the lowest effective dosage of medroxyprogesterone. Women should be evaluated every three to six months to determine if treatment is still needed.
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Medroxyprogesterone Drug Information

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