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Treatment Guidelines for Medroxyprogesterone

Medroxyprogesterone Injection Dosing Guidelines

The standard dosage of medroxyprogesterone intramuscular injection (Depo-Provera) for preventing pregnancy is 150 mg every 3 months (13 weeks).
 
The standard dose of medroxyprogesterone subcutaneous injection (depo-subQ Provera 104) for preventing pregnancy is 104 mg every 3 months (every 12 to 14 weeks). The same amount is used for relieving symptoms of endometriosis.
 
Your first medroxyprogesterone injection should only be given at a time when pregnancy is not a possibility, such as:
 
  • The first five days of the menstrual period
  • The first five days after birth in women who are not breastfeeding
  • The sixth week after birth in women who are breastfeeding.
     
The standard initial dosage for relieving symptoms of renal cancer (kidney cancer) and endometrial cancer is medroxyprogesterone intramuscular injection 400 mg to 1000 mg per week. The actual dose will vary from person to person. If symptoms improve and the cancer appears to be stable, the dosage may be decreased to as little as 400 mg once a month.
 

General Information on Using Medroxyprogesterone

Some considerations to keep in mind during treatment with medroxyprogesterone include the following:
 
  • This medication comes in different forms. The oral form (tablet form) is usually taken by mouth once a day. The injectable forms are given every three months to prevent pregnancy.
     
  • Injectable medroxyprogesterone is usually given by a healthcare provider in a healthcare setting.
     
  • Medroxyprogesterone doses can be taken with or without food. Try taking the medicine with food if it bothers your stomach.
     
  • Try to take the oral form at the same time each day, both to help you remember to take it and to keep an even level of the drug in your bloodstream.
     
  • For this drug to work properly, it must be used as prescribed.
     
  • If you are unsure about anything related to dosing with medroxyprogesterone, please talk with your healthcare provider, nurse, or pharmacist.
     
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Medroxyprogesterone Drug Information

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