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Precautions and Warnings With Maraviroc

There are a number of precautions and warnings with maraviroc to be aware of before starting treatment. For example, the drug can potentially cause liver damage and may increase the risk of infections and certain cancers. Precautions and warnings with maraviroc also extend to people who have certain health conditions, such as liver disease, heart disease, or any allergies.

Maraviroc: What Should I Tell My Healthcare Provider?

You should talk with your healthcare provider prior to taking maraviroc (Selzentry™) if you have:
 
  • Liver disease, such as liver failure, cirrhosis, or hepatitis
  • Kidney disease, including kidney failure (renal failure)
  • Heart disease or any other heart problems
  • Low blood pressure (hypotension)
  • Any allergies, including allergies to food, dyes, or preservatives.
     
Also, let your healthcare provider know if you are:
 
  • Pregnant or thinking of becoming pregnant
  • Breastfeeding.
     
You should also be sure to tell your healthcare provider about any other medicines you are taking, including prescription and non-prescription medicines, vitamins, and herbal supplements.
 

Specific Precautions and Warnings With Maraviroc

Warnings and precautions to be aware of prior to taking maraviroc include the following:
 
  • Maraviroc should not be your only HIV medication. It should always be used in combination with other HIV drugs.
     
  • Maraviroc can cause liver damage. If you already have liver disease, your healthcare provider may need to monitor you more closely during treatment. 
  • Sometimes, liver damage with maraviroc occurs along with a rash or other signs of an allergic reaction. These cases usually occur about one month after the drug was first started. Therefore, skin rashes with this medication should be taken seriously, as they may signal potential liver damage.
  • In studies, maraviroc appeared to increase the risk of heart attacks. If you have heart disease (or are at a high risk for heart disease), your healthcare provider may need to monitor you more closely during treatment.
     
  • The medication sometimes lowers blood pressure, which may be a problem if you already have low blood pressure.
     
  • Because of the way maraviroc works, theoretically, it may increase the risk of infections or certain cancers because it may affect the way certain immune cells work.
     
  • When you first start taking maraviroc, your immune system starts to work better, which may cause you to react to infections that are already present in your body (before, your immune system may have been too weak to respond to the infections). You may find that you have infections you did not know you had.
     
  • Maraviroc is not a cure for HIV or AIDS. If you have HIV or AIDS, you should always use safer sex practices, whether or not you are taking medications.
     
  • As with all HIV medications, it is important that you take maraviroc exactly as prescribed. Missing doses may increase the chance of the virus becoming resistant to HIV medications.
     
  • Maraviroc can interact with a number of different medications (see Drug Interactions With Maraviroc).
     
  • Maraviroc is considered a pregnancy Category B medication. This means that it is probably safe for use during pregnancy, although the full risks are not known (see Selzentry and Pregnancy).
     
  • It is not known if maraviroc passes through breast milk. Therefore, if you are breastfeeding or plan to start, discuss this with your healthcare provider prior to taking the drug (see Selzentry and Breastfeeding). It is important to understand that the HIV virus can be transmitted through breast milk and that breastfeeding is usually not recommended in women who have HIV or AIDS.
     

Maraviroc for HIV/AIDS

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