Drug Interactions With Maraviroc (Cont.)

Maraviroc Interactions Explained

The following sections explain in detail the potentially negative interactions that can occur when maraviroc is combined with any of the drugs listed above.
 
Certain Antibiotics or Antifungals
Some antibiotics or antifungals can increase the level of maraviroc in your blood. If you take one of these medications, your healthcare provider may recommend a lower maraviroc dosage.
 
Certain Seizure Medications
Some seizure medications may decrease the level of maraviroc in your blood. If you take any of these seizure medications, your healthcare provider may recommend a higher maraviroc dose.
 
Delavirdine
Delavirdine may increase the level of maraviroc in your blood. In these cases, your healthcare provider may recommend a lower dose of maraviroc to prevent this interaction from occurring.
 
Efavirenz
Efavirenz may decrease the level of maraviroc in your blood, and your healthcare provider may need to increase your maraviroc dose to prevent this.
 
Most Protease Inhibitors
Most protease inhibitors increase the level of maraviroc in your blood. Check with your healthcare provider before combining maraviroc with a protease inhibitor, as you may need a lower maraviroc dose. This interaction does not apply to tipranavir (Aptivus®) and ritonavir (Norvir).
 
Nefazodone
Nefazodone increases the level of maraviroc in your blood. If you take both of these medications, your healthcare provider may recommend a lower maraviroc dosage.
 
Rifampin
Rifampin may decrease the level of maraviroc in your blood, and your healthcare provider may need to increase your maraviroc dose as a result.
(Drug Interactions With Maraviroc Continued: Page 3)

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Written by/reviewed by: Kristi Monson, PharmD; Arthur Schoenstadt, MD
Last reviewed by: Kristi Monson, PharmD;