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Veregen is licensed for the treatment of external genital and perianal warts. This prescription medicine comes in the form of an ointment that is applied to the warts three times a day until the warts are gone. While most people who use this product do not experience problems with it, side effects are possible and may include pain, burning, or itching of the skin.


What Is Veregen?

Veregen® (sinecatechins) is a prescription medication approved to treat external genital warts and perianal warts. It is the first botanical prescription drug approved in the United States. It is "botanical" because it is made from green tea leaf extract.
(Click Veregen Uses for more information on this topic, including possible off-label uses.)

Who Makes This Medicine?

Veregen is made by C.P.M. Contract Pharma GmbH & Co. KG (a manufacturer in Germany) for PharmaDerm.

How Does Veregen Work?

It is not entirely clear how Veregen works to treat genital warts, although it is thought that its effects might be due to activation of the immune system.

Clinical Effects

This medication has been thoroughly evaluated in clinical studies. These studies compared Veregen to a placebo (an ointment with no active ingredient). These studies demonstrated that Veregen was significantly more effective than the placebo for eliminating genital or perianal warts. In studies, 53.6 percent of people using this drug had complete disappearance of warts, compared to only 35.3 percent of people using the placebo.

When and How to Use It

Some general considerations to keep in mind during treatment with Veregen include the following:
  • This medication comes in the form of an ointment that is applied to the wart(s) three times a day.
  • Apply the ointment until the warts are gone (up to 16 weeks). 
  • Wash your hands before and after applying Veregen.
  • Wash the ointment off before having sex. Veregen can weaken condoms or diaphragms.
  • For the medication to work properly, it must be used as prescribed.  
Written by/reviewed by:
Last reviewed by: Kristi Monson, PharmD;
Last updated/reviewed:
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