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Tri-Norinyl Interactions Explained

The following sections explain in detail the potentially negative interactions that can occur when Tri-Norinyl is combined with any of the drugs listed above. Anytime a backup method of birth control is recommended, make sure your healthcare provider explains how long you need to use the backup (in some situations, it may be longer than you might think).
 
Aminoglutethimide (Cytadren)
Taking Tri-Norinyl and aminoglutethimide together increases the risk of pregnancy. Do not use these medications together without first talking to your healthcare provider. You may need to use a backup method of contraception (such as condoms).
 
Antibiotics
There have been reports of accidental pregnancy occurring in women taking birth control pills together with certain antibiotics. However, the significance of this interaction is still uncertain. Some antibiotics are more likely to cause problems than others. Any time you take an antibiotic, make sure to ask your healthcare provider if you need to use a backup method of contraception.
 
Aprepitant (Emend)
Aprepitant can make Tri-Norinyl less effective, perhaps increasing your chance of pregnancy. Talk with your healthcare provider before using these medications together. You may need to use a backup method of contraception. People undergoing chemotherapy commonly use aprepitant, and it is usually very important for women having chemotherapy to avoid pregnancy.
 
Barbiturate Medications
Barbiturates may cause your body to metabolize the hormones in Tri-Norinyl too quickly, increasing your risk of pregnancy. Ask your healthcare provider if you should use a different method of contraception while taking a barbiturate.
 
Cyclosporine (Gengraf, Neoral, Sandimmune)
Tri-Norinyl may increase the level of cyclosporine in your blood, increasing the chance of side effects of cyclosporine. Talk with your healthcare provider before taking these medications together. You may need a lower cyclosporine dose, or you may need to switch to a different method of contraception.
Written by/reviewed by:
Last reviewed by: Kristi Monson, PharmD;
Last updated/reviewed:
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