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Headache, diarrhea, nausea, and weakness appear to be some of the most common side effects of tenofovir. Other possible side effects include indigestion or heartburn, chest pain, and drowsiness. While most tenofovir side effects are minor, there are a number of side effects that should be reported to your healthcare provider immediately, including high cholesterol or triglycerides, kidney problems, depression, and anxiety.

Side Effects of Tenofovir: An Introduction

As with any medicine, side effects are possible with tenofovir disoproxil fumarate (Viread®); however, not everyone who takes the drug will experience side effects. In fact, most people tolerate it quite well. If side effects do occur, in most cases, they are minor and either require no treatment or can easily be treated by you or your healthcare provider.
(This article covers many, but not all, of the possible side effects with tenofovir. Your healthcare provider can discuss a more complete list of tenofovir side effects with you.)

Side Effects of Tenofovir to Report

Some side effects with tenofovir, while occurring infrequently, are potentially serious and should be reported to your healthcare provider right away. These include but are not limited to:
    • Feeling tired or weak
    • Muscle pain
    • Trouble breathing
    • Stomach pain
    • Feeling cold
    • Cold or blue hands and feet
    • Dizziness or lightheadedness
    • A slow or irregular heartbeat
    • Persistent nausea, vomiting, and abdominal pain
    • Shortness of breath
    • An enlarged or tender liver
    • Weight loss
  • Changes in the distribution of fat on your body (such as a "buffalo hump")
  • Signs of an allergic reaction, such as:
    • A rash
    • Hives
    • Itching
    • Swelling of the mouth or throat
    • Wheezing
    • Difficulty breathing.
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Last reviewed by: Kristi Monson, PharmD;
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