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Although Skyla has not been studied with other drugs, the active ingredient in this product is believed to interact with protease inhibitors, acitretin, bosentan, and several other medications. To help reduce your risk of interactions, tell your healthcare provider about all other products you are taking, including vitamins, herbal supplements, and prescription and nonprescription medications.

An Overview of Interactions With Skyla

Skyla™ (levonorgestrel-releasing intrauterine system) has not been studied with other medications, and it is not entirely known whether it interacts with other medicines. Skyla contains levonorgestrel, a progesterone hormone found in certain birth control pills. Oral levonorgestrel can interact with many other medications.
However, unlike birth control pills, Skyla is not taken by mouth. It is inserted into the uterus, where it slowly releases the active drug. It is unknown whether this method of drug delivery would interact with other medications in the same manner as birth control pills.
Based on interactions with levonorgestrel, possible Skyla drug interactions may include but are not limited to:
  • Non-nucleoside reverse transcriptase inhibitor (NNRTI) HIV medications, such as:
    • Delavirdine (Rescriptor®)
    • Efavirenz (Sustiva®)
    • Nevirapine (Viramune®)
  • Protease inhibitors, such as:
    • Amprenavir (Agenerase®)
    • Atazanavir (Reyataz®)
    • Darunavir (Prezista®)
    • Fosamprenavir (Lexiva®)
    • Indinavir (Crixivan®)
    • Lopinavir and ritonavir (Kaletra®)
    • Nelfinavir (Viracept®)
    • Ritonavir (Norvir®)
    • Saquinavir (Fortovase®, Invirase®)
    • Tipranavir (Aptivus®)
Written by/reviewed by:
Last reviewed by: Kristi Monson, PharmD;
Last updated/reviewed:
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