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Saquinavir dosing guidelines take several factors into account, such as other existing medical conditions and other medications you are taking. For people who are at least 16 years old, the saquinavir dosage is 1000 mg twice daily with 100 mg of ritonavir twice daily. It is important that you take the medication as scheduled; skipping doses may cause the HIV virus to become resistant to saquinavir.

Saquinavir Dosing: An Introduction

The dose of saquinavir mesylate (Invirase®) that your healthcare provider recommends will vary, depending on a number of factors, including:
 
  • Other medical conditions you may have
  • Other medications you may be currently taking.
     
As always, do not adjust your dose unless your healthcare provider specifically instructs you to do so.
 

Saquinavir Dosing for HIV and AIDS

Saquinavir is always combined with ritonavir (Norvir®), another HIV medication that increases the level of saquinavir in the blood, making it more effective. The recommended dose of saquinavir for treating adults and adolescents age 16 and older with HIV or AIDS is saquinavir 1000 mg twice daily with ritonavir 100 mg twice daily. Both medications should be taken at the same time. In order to get 1000 mg of saquinavir, either five 200-mg capsules or two 500-mg tablets may be taken.
 

General Information on Dosing With Saquinavir

Considerations for people taking saquinavir include the following:
 
  • The medication comes in the form of a capsule and a tablet. It is usually taken by mouth twice daily.
     
  • Saquinavir should be taken with a meal or within two hours after a meal. It is always used along with ritonavir, and saquinavir and ritonavir should be taken at the same time.
     
  • Try to take saquinavir at the same times every day to maintain an even level in your blood.
     
  • For the medication to work properly, it must be taken as prescribed. It is very important that you closely follow your healthcare provider's instructions for taking saquinavir. Missing doses can increase the chance of the virus developing a resistance to the medication, thereby making it less effective.
     
  • If you are unsure about anything related to saquinavir dosing, please talk to your doctor, nurse, or pharmacist. Do not stop taking the drug without first discussing it with your healthcare provider.
     
Written by/reviewed by:
Last reviewed by: Kristi Monson, PharmD;
Last updated/reviewed:
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