STD Home > More Medicines That React With Saquinavir

Hormonal Contraceptives
Saquinavir can make hormonal contraceptives less effective. You should use a non-hormonal method of contraception (such as condoms) while taking saquinavir.
 
Immune-Suppressing Medications
Saquinavir may increase the level of some immune-suppressing medications in your blood. Your healthcare provider may need to decrease the dose of your immune-suppressing medication to prevent this.
 
Methadone
Saquinavir can decrease the level of methadone in your blood, perhaps making it less effective. Your healthcare provider may need to increase your methadone dosage as a result.
 
Nevirapine
Nevirapine may decrease the level of saquinavir in your blood. Your healthcare provider may need to increase your saquinavir dosage or may suggest a different combination of HIV medications.
 
Phosphodiesterase Type 5 Inhibitors (PDE5 Inhibitors)
Saquinavir can increase the level of PDE5 inhibitors in your blood, increasing your risk of side effects. Your healthcare provider may recommend a lower-than-typical dosage for your PDE5 inhibitor while you are taking saquinavir.
 
PDE5 inhibitors are used to treat erectile dysfunction or pulmonary arterial hypertension. Specific dosing recommendations are available for combining saquinavir with a PDE5 inhibitor if the PDE5 inhibitor is used to treat erectile dysfunction. Also, specific dosing recommendations are available for combining saquinavir with tadalafil when tadalafil is used to treat pulmonary arterial hypertension.
 
However, at this time it is not recommended to combine saquinavir with sildenafil when sildenafil is used to treat pulmonary arterial hypertension, as a safe and effective dosing regimen has not yet been determined for this situation.
Written by/reviewed by:
Last reviewed by: Kristi Monson, PharmD;
Last updated/reviewed:
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