STD Home > More Info on Ritonavir Interactions

Didanosine must be taken on an empty stomach, while ritonavir must be taken with food. Therefore, be sure to take these medications at different times of the day.
Ritonavir may increase the level of digoxin in your blood, possibly increasing your risk of dangerous digoxin side effects. Your healthcare provider should monitor the level of digoxin in your blood and adjust your dose as necessary.
Both ritonavir capsules and oral solution contain alcohol. Do not take ritonavir and disulfiram together, as dangerous side effects may occur due to the alcohol in ritonavir.
Ritonavir may increase the level of dronabinol in your blood. Your healthcare provider may need to decrease your dronabinol dosage to prevent this interaction from occurring.
Ergot Medications
Ritonavir should not be combined with ergot medications, due to the risk of dangerous side effects.
Ritonavir tends to increase fentanyl levels, potentially increasing the risk of dangerous side effects, unless the fentanyl dosage is adjusted accordingly.
Hormonal Contraceptives
Ritonavir may make hormonal contraceptives less effective. You should use a non-hormonal method of contraception (such as condoms) while taking ritonavir.
Immune-Suppressing Medications
Ritonavir may increase the level of some immune-suppressing medications in your blood. Your healthcare provider may need to decrease the dose of your immune-suppressing medication as a result.
Combining meperidine with ritonavir may increase the risk of dangerous meperidine side effects. Ask your healthcare provider before taking these medications together.
Written by/reviewed by:
Last reviewed by: Kristi Monson, PharmD;
Last updated/reviewed:
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