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Several medications should not be taken with Ortho Tri-Cyclen Lo. Drug interactions could be severe enough to cause unintentional pregnancy, so make sure to talk to your healthcare provider before taking any medications with Ortho Tri-Cyclen Lo. Drug interactions may occur if the birth control pill is combined with antibiotics, barbiturates, St. John's wort, or protease inhibitors.

Ortho Tri-Cyclen Lo Drug Interactions: An Overview

Ortho Tri-Cyclen Lo® (norgestimate/ethinyl estradiol) can potentially interact with numerous other medicines. Many of these interactions can be severe enough to cause unintentional pregnancy. If you are not sure about any particular Ortho Tri-Cyclen Lo drug interaction, it is a good idea to use a backup method of contraception, such as condoms, until you can check with your healthcare provider. Some of the medications that may lead to Ortho Tri-Cyclen Lo drug interactions include:
  • Aminoglutethimide (Cytadren®)
  • Antibiotics
  • Aprepitant (Emend®)
  • Atorvastatin (Lipitor®) or combination medications that contain atorvastatin (Caduet®, Liptruzet™)
  • Barbiturate medications, such as:
    • Amobarbital (Amytal®)
    • Butalbital (Fioricet®, Fiorinal®)
    • Pentobarbital (Nembutal®)
    • Phenobarbital (Luminal®)
    • Secobarbital (Seconal®)
Written by/reviewed by:
Last reviewed by: Kristi Monson, PharmD;
Last updated/reviewed:
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