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Medications that may cause drug interactions with oral contraceptives include barbiturates, protease inhibitors, and aprepitant, among others. These reactions can either reduce the effectiveness of the oral contraceptive or cause your body to metabolize the hormones in the oral contraceptive too quickly (which also increases your risk of becoming pregnant). To reduce your risk of interactions, tell your healthcare provider about all your medications.

An Overview of Interactions With Oral Contraceptives

Oral contraceptives (birth control pills) can potentially react with several other medicines. Many of these interactions can be severe enough to lead to unintentional pregnancy. If you are not sure about a particular oral contraceptive drug interaction, you should use a backup method of birth control, such as condoms, until you can check with your healthcare provider.
Some of the medications that may lead to oral contraceptive drug interactions include:
  • Aminoglutethimide (Cytadren®)
  • Antibiotics
  • Aprepitant (Emend®)
  • Barbiturate medications, such as:
    • Amobarbital (Amytal®)
    • Butalbital (Fioricet®, Fiorinal®)
    • Pentobarbital (Nembutal®)
    • Phenobarbital (Luminal®)
    • Secobarbital (Seconal®)
  • Many seizure medications, such as:
Written by/reviewed by:
Last reviewed by: Kristi Monson, PharmD;
Last updated/reviewed:
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