STD Home > More Medications That Can Interfere With Nelfinavir

Ergot Medications
Nelfinavir should not be combined with ergot medications, due to the risk of dangerous side effects.
 
Fluticasone or Combination Medications That Contain Fluticasone
Nelfinavir may increase the level of fluticasone in your blood. Check with your healthcare provider before taking nelfinavir with fluticasone.
 
Immune-Suppressing Medications
Nelfinavir may increase the level of some immune-suppressing medications in your blood. Your healthcare provider may need to decrease the dose of your immune-suppressing medication.
 
Methadone (Dolophine, Methadose)
Nelfinavir may decrease the level of methadone in your blood. Your healthcare provider may need to increase your methadone dosage.
 
Nevirapine (Viramune)
Nevirapine can decrease the level of nelfinavir in your blood. Your healthcare provider may need to increase your nelfinavir dosage or recommend a different combination of medications.
 
Oral Contraceptives (Birth Control Pills)
Nelfinavir may make oral contraceptives less effective. You should use a non-hormonal method of contraception (such as condoms) while taking nelfinavir.
 
Other Protease Inhibitors
Taking nelfinavir together with another protease inhibitor may increase the level of both medications in your blood. Check with your healthcare provider before taking two protease inhibitors together.
 
Phosphodiesterase Type 5 Inhibitors (PDE5 Inhibitors)
Nelfinavir can increase the level of PDE5 inhibitors in your blood, increasing your risk of side effects. You should not take more than 25 mg of sildenafil in 48 hours, 10 mg of tadalafil in 72 hours, or 2.5 mg of vardenafil in 72 hours while taking nelfinavir.
Written by/reviewed by:
Last reviewed by: Kristi Monson, PharmD;
Last updated/reviewed:
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