STD Home > Possible Reactions to Medroxyprogesterone

Common Side Effects

For many medications, the prescribing information carefully explains the exact percentage of side effects that were seen in clinical trials. However, the prescribing information for almost all older medications, including medroxyprogesterone, includes only vague side effect information, with no exact percentages. Therefore, it can be difficult to know exactly how common the side effects of such medications may be.
Based on side effects reported in women taking progestin hormones, including medroxyprogesterone, possible adverse reactions to this product may include but are not limited to:
  • Irregular menstrual periods
  • Spotting
  • Breast tenderness or pain
  • Headache
  • Vaginal bleeding, such as breakthrough bleeding or spotting
  • An absence of menstrual periods (amenorrhea)
  • Vaginal secretions
  • Nervousness
  • Depression
  • Dizziness
  • Drowsiness or fatigue
  • Insomnia
  • Acne
  • Rash and itching
  • Abdominal pain (stomach pain)
  • Nausea
  • Bloating
  • Swelling
  • Fever
  • Weight gain or weight loss
  • Milky secretion from the nipples (galactorrhea)
  • Loss of hair or increased hair growth
  • Depression.
Medroxyprogesterone intramuscular injection (Depo-Provera) and medroxyprogesterone subcutaneous injection (depo-subQ Provera 104) may have slightly different side effects than the oral form of the drug (Provera). Some of the more common reactions to injectable forms of medroxyprogesterone include:
  • Weight gain
  • Lack of a menstrual period (amenorrhea)
  • Skin reactions at the injection site.
Written by/reviewed by:
Last reviewed by: Kristi Monson, PharmD;
Last updated/reviewed:
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