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When and How to Take Lopinavir and Ritonavir

General considerations for when and how to take lopinavir and ritonavir include the following:
  • The medication comes in tablet and oral solution (liquid) form. It is usually taken by mouth once or twice daily.
  • You can take lopinavir and ritonavir tablets with or without food. If it bothers your stomach, try taking it with food. Lopinavir and ritonavir oral solution must always be taken with food.
  • Do not break, chew, or crush lopinavir and ritonavir tablets.
  • Try to take lopinavir and ritonavir at the same time(s) every day to maintain an even level in your blood.
  • For the medication to work properly, it must be taken as prescribed. It is very important that you closely follow your healthcare provider's instructions about taking lopinavir and ritonavir. Missing doses can increase the chance of the virus developing resistance to the drug, thereby making it less effective.

Dosage Information for Lopinavir and Ritonavir

The dose of lopinavir and ritonavir that your healthcare provider recommends will vary, depending on a number of factors, including:
  • Your age
  • Which drug resistance mutations your particular HIV virus has developed 
  • Your weight (for children)
  • Other medical conditions you may have
  • Other medications you may be currently taking.
As always, do not adjust your dose unless your healthcare provider specifically instructs you to do so.
(Click Lopinavir and Ritonavir Dosing for more information.)
Written by/reviewed by:
Last reviewed by: Kristi Monson, PharmD;
Last updated/reviewed:
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