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Lopinavir and Ritonavir Interactions Explained

The following sections explain in detail the potentially negative interactions that can occur when lopinavir and ritonavir is combined with any of the drugs listed above.
Lopinavir and ritonavir should not be combined with alfuzosin, as this may increase the amount of alfuzosin in the blood to dangerous levels.
Anticoagulation Medications
Lopinavir and ritonavir may affect warfarin, and close monitoring is required while taking these two medications together. Lopinavir and ritonavir may increase the levels of rivaroxaban in your blood, increasing the risk of dangerous bleeding. It is not recommended that these medications be taken together. 
Arrhythmia Medications
Lopinavir and ritonavir may increase the level of certain arrhythmia medications in your blood, possibly increasing the risk of dangerous side effects. Talk with your healthcare provider before taking lopinavir and ritonavir with one of these medications.
Lopinavir and ritonavir may decrease the level of atovaquone in your blood, perhaps making it less effective. Your healthcare provider may need to increase your atovaquone dosage to prevent this interaction from occurring.
Beta Blockers
Combining lopinavir and ritonavir with a beta blocker may increase the risk of a certain irregular heart rhythm known as heart block. This may potentially be quite dangerous. If you take such medications together, your healthcare provider may want to monitor your heart to check for this problem.
Lopinavir and ritonavir may increase the level of bosentan in your blood. Your healthcare provider may need to lower your bosentan dosage while you are taking lopinavir and ritonavir.
Written by/reviewed by:
Last reviewed by: Kristi Monson, PharmD;
Last updated/reviewed:
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