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Lamivudine/zidovudine is a combination medication used in the treatment of HIV infection or AIDS. By combining two different HIV medications, the drug is more effective than when just one of these drugs is used alone. It works by preventing the HIV virus from multiplying and infecting healthy cells. Possible side effects of lamivudine/zidovudine include headaches, nausea, and fatigue.

What Is Lamivudine/Zidovudine?

Lamivudine/zidovudine (Combivir®) is a prescription medication used to treat HIV infection or AIDS. It is approved for use in combination with other HIV medications as a treatment for HIV. Lamivudine/zidovudine, as the name implies, contains two different medications: lamivudine (Epivir®, 3TC) and zidovudine (Retrovir®, AZT, ZDV).
(Click What Is Lamivudine/zidovudine Used For? for more information, including possible off-label uses.)

Lamivudine/Zidovudine Side Effects

As with any medicine, side effects are possible with lamivudine/zidovudine. However, not everyone who takes the drug will experience side effects. In fact, most people tolerate it quite well. If side effects do occur, in most cases, they are minor and either require no treatment or can easily be treated by you or your healthcare provider. Serious side effects are less common.
Common side effects of lamivudine/zidovudine include, but are not limited to:
  • Headaches
  • Nausea
  • A general ill feeling (malaise) and fatigue
  • Nasal symptoms.
(Click Side Effects of Lamivudine/zidovudine to learn more, including potentially serious side effects that you should report immediately to your healthcare provider.)
Written by/reviewed by:
Last reviewed by: Kristi Monson, PharmD;
Last updated/reviewed:
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