STD Home > Precautions and Warnings With Fosamprenavir

Being aware of precautions and warnings with fosamprenavir before starting the drug can help ensure a safe treatment process. Tell your healthcare provider if you have liver disease, high triglycerides, diabetes, or hemophilia before taking fosamprenavir. Precautions and warnings also apply to people who are allergic to amprenavir or any components of fosamprenavir, or who are taking medications that may cause an interaction.

Fosamprenavir: What Should I Tell My Healthcare Provider?

You should talk with your healthcare provider prior to taking fosamprenavir calcium (Lexiva®) if you have:
Also, let your healthcare provider know if you are:
  • Pregnant or thinking of becoming pregnant
  • Breastfeeding.
You should also be sure to tell your healthcare provider about all other medicines you are taking, including prescription and non-prescription medicines, vitamins, and herbal supplements.

Specific Precautions and Warnings With Fosamprenavir

Warnings and precautions to be aware of prior to taking fosamprenavir include the following:
  • The medication can destroy red blood cells (this is known as hemolytic anemia).
  • Fosamprenavir frequently causes skin rashes. Most often, these rashes are harmless, although they can be quite dangerous sometimes. Let your healthcare provider know if you develop a rash while taking the medication.
  • Fosamprenavir is a sulfonamide ("sulfa") drug. If you have a sulfa allergy, do not take fosamprenavir without checking with your healthcare provider first.
  • The liver helps to remove fosamprenavir from the blood. Therefore, if you have liver disease, fosamprenavir may make it worse. Make sure to tell your healthcare provider if you already have liver disease or liver damage prior to taking the drug.
  • Fosamprenavir can cause high blood sugar (hyperglycemia). This can cause problems for people with diabetes, or it can even cause diabetes in individuals who are at risk for the condition.
  • There have been reports of bleeding possibly due to protease inhibitors (such as fosamprenavir) in people with hemophilia. Be sure your healthcare provider knows if you have this condition.
  • Fosamprenavir can increase triglyceride and cholesterol levels. Your healthcare provider should check your triglyceride and cholesterol levels regularly while you are taking the medication.
  • In rare cases, kidney stones have been reported in people taking fosamprenavir. It is unclear if this was actually related to Lexiva or was merely coincidental. Nevertheless, be sure to talk with your healthcare provider if you have a history of kidney stones.
  • Fosamprenavir can change the distribution of fat on your body. You may gain fat in areas that are not typical for you, such as in the abdomen or at the back of the neck (a "buffalo hump"), and may lose weight in other areas.
  • Fosamprenavir is not a cure for HIV or AIDS. If you have HIV or AIDS, you should always use safer sex practices, whether or not you are taking medications.
  • As with all HIV medications, it is important that you take fosamprenavir exactly as prescribed. Missing doses may increase the chance of the virus becoming resistant to HIV medications.
  • Fosamprenavir can interact with a number of different medications (see Drug Interactions With Fosamprenavir).
  • Fosamprenavir is considered a pregnancy Category C medication. This means that it may not be safe for use during pregnancy, although the full risks are not known (see Lexiva and Pregnancy).
  • It is not known if fosamprenavir passes through breast milk. Therefore, if you are breastfeeding or plan to start, discuss this with your healthcare provider prior to taking the drug (see Lexiva and Breastfeeding). It is important to understand that the HIV virus can be transmitted through breast milk and that breastfeeding is usually not recommended in women with HIV or AIDS.
Written by/reviewed by:
Last reviewed by: Kristi Monson, PharmD;
Last updated/reviewed:
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