STD Home > More Info on Etravirine Indications

How Does It Work?

Etravirine belongs to a group of HIV medications known as non-nucleoside reverse transcriptase inhibitors (NNRTIs). These medicines work by blocking a process that the HIV virus needs in order to multiply.
 
HIV (human immunodeficiency virus) is the virus that causes AIDS. Like other viruses, HIV must use a person's own cells to reproduce. However, HIV is a little different from most other viruses because it must first convert its genetic material from RNA to DNA. It is the DNA genes that allow HIV to multiply.
 
HIV converts its genetic material by using a special protein called the reverse transcriptase enzyme. To create DNA, this enzyme uses several different molecular building blocks.
 
Etravirine works by attaching to the reverse transcriptase enzyme, stopping it from making DNA. Without DNA, HIV cannot multiply. Etravirine is not a cure for HIV or AIDS. It can help stop HIV from infecting uninfected cells in the body, but it does not help cells that have already been infected with the virus.
 

Etravirine Use in Children

Etravirine is approved for use in children six years of age and older. It is not approved for use in children younger than age six. Talk with your child's healthcare provider about the benefits and risks of using etravirine in children.
 

Etravirine Use in Older Adults

Clinical trials of etravirine did not include many people older than age 65. Therefore, it is unknown whether older adults will respond to the medicine any differently than younger age groups. At this time, no differences in responses between older and younger adults have been reported. However, older adults may be more likely to be taking other medicines and to have other medical conditions, and therefore may need to be carefully monitored.
  
Written by/reviewed by:
Last reviewed by: Kristi Monson, PharmD;
Last updated/reviewed:
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